-- DavidKeating - 20 Oct 2008

Module 14 - small amplitude ERG

To be completed by (Caruso + Wilke+Zrenner)

1. Scope

For dark-adapted conditions in patients with minimal ERG responses

2. Identification

2.1. Number

14

2.2. Version number

1.0

2.3. Date of approval

3. Protocol use(s)

Detection of diffuse dysfunction in the rod pathway;

Assessment of rod phototransduction dynamics;

4. Patient population

Genetic rod-cone degenerations

5. Technical issues

4.1. Equipment and facilities

No specific definition, see ISCEV Standard (2008 update) and Protocols general aspects.

4.2. Staff expertise and responsibilities

No specific definition, see ISCEV Standard (2008 update) and Protocols general aspects.

4.3. Procedure

No specific definition, see ISCEV Standard (2008 update) and Protocols general aspects.

4.4. Patient Information

No specific definition, see ISCEV Standard (2008 update) and Protocols general aspects.

6. Response evaluation (with example)

Fourier analysis + noise filtering;

7. Reporting and storage

Curves, amplitudes, latencies;

8. Calibration

No specific definition, see ISCEV Standard (2008 update) and Protocols general aspects.

9. Protocol Specifications

Description

9 Hz Flicker

Averages per step

4

Adaptation time

0

Acquisition

Sample frequency

2000 (Hz)

Sweep pre-trigger time

0 (ms)

Sweep post-trigger time

444 (ms)

Sweeps per result

30

Interstimulus interval

0 (ms)

Drift removal

On

Manual rejection of sweeps

Off

DC off-set removal

On: 20 (ms)

Stimulus

Pulse frequency

9 Hz

Pulse duration (d)

10 (ms)

Stimulus luminance

0.012 sc cd.s/m²

Stimulus color

Blue

Background luminance

0 cd/m2

Background color

White 6500K

Channels (1 and 2)

Filter low frequency cutoff

1.5 (Hz)

Filter high frequency cutoff

30 (Hz)

Y-axis scaling

20 (uV)

10. Relevant References

Topic revision: r3 - 06 Feb 2009 - 16:26:50 - TWikiAdminUser
 
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